![]() ![]() ![]() Cartilage damage and synovitis were estimated by Mankin’s and Krenn’s scores, respectively, and histological techniques. After sacrifice, subchondral bone integrity was assessed in the tibiae by microCT and histology. CM was performed using the chiropractic instrument ActivatorV 3 times/week for 8 weeks as follows: force 2 setting was applied to the tibial tubercle of the rabbit right hind limb (TM-OA), whereas the corresponding left hind limb received a false manipulation (FM-OA) consisting of ActivatorV firing in the air and slightly touching the tibial tubercle. Male New-Zealand rabbits underwent knee surgery to induce OA by anterior cruciate ligament injury. We here assessed whether CM might ameliorate OA by improving subchondral bone sclerosis, cartilage integrity and synovitis. Our previous study showed that in experimental osteoporosis, chiropractic manipulation (CM) exerts protective effects on bone. ![]() Osteoarthritis (OA) is a degenerative disease characterized by injury of all joint tissues. ![]()
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